کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1376510 | 981959 | 2006 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis](/preview/png/1376510.png)
New free radical scavengers, inoscavin D (1) and methylinoscavin D (2), were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compounds phelligridin D (3), 3,4-dihydroxybenzaldehyde (4), and 3,4-dihydroxybenzoic acid (5). Their structures were established by various spectroscopic analyses. Compounds 1 and 3 were proposed to be biosynthesized from the oxidative coupling of the precursor hispidin with 3,4-dihydroxybenzaldehyde and 3,4-dihydroxybenzoic acid, respectively. These compounds exhibited significant scavenging activity against the ABTS radical cation, and compounds 2 and 4 displayed moderate superoxide radical scavenging activity.
New free radical scavengers 1 and 2 were isolated from the methanolic extract of the fruiting body of the medicinal mushroom Inonotus xeranticus, along with the known compounds phelligridin D, 3,4-dihydroxybenzaldehyde, and 3,4-dihydroxybenzoic acid. Their structures were established by extensive spectroscopic data. Compounds 1 and 3 were proposed to be biosynthesized from the oxidative coupling of the precursor hispidin with 3,4-dihydroxybenzaldehyde and 3,4-dihydroxybenzoic acid, respectively. These compounds exhibited significant free radical scavenging activityFigure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 21, 1 November 2006, Pages 5621–5624