کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376516 981959 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands
چکیده انگلیسی

Two potential bioisosteres of the nonsteroidal antiandrogen bicalutamide, an imidazolidinone and an indole, were synthesized and tested for their androgen receptor binding. Indole was discovered to be a suitable bioisostere for the acyl anilide moiety in the parent compound. Several analogs in the indole series were found to be 10-fold better than bicalutamide in binding to the recombinant androgen receptor binding domain.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 21, 1 November 2006, Pages 5646–5649
نویسندگان
, , , , , ,