کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376550 | 981961 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase](/preview/png/1376550.png)
چکیده انگلیسی
We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency.
A series of small molecule inhibitors of the lymphoid specific tyrosine phosphatase were described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 9, 1 May 2008, Pages 2840–2844
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 9, 1 May 2008, Pages 2840–2844
نویسندگان
Yuli Xie, Yidong Liu, Gangli Gong, Alison Rinderspacher, Shi-Xian Deng, Deborah H. Smith, Udo Toebben, Effie Tzilianos, Lars Branden, Dušica Vidović, Caty Chung, Stephan Schürer, Lutz Tautz, Donald W. Landry,