کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376555 981961 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif
چکیده انگلیسی

2-Cyano-6-fluorophenylacetamide was explored as a novel P2 scaffold in the design of thrombin inhibitors. Optimization around this structural motif culminated in 14, which is a potent thrombin inhibitor (Ki = 1.2 nM) that exhibits robust efficacy in canine anticoagulation and thrombosis models upon oral administration.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 9, 1 May 2008, Pages 2865–2870
نویسندگان
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