کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1376600 | 981962 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma](/preview/png/1376600.png)
We have previously reported substituted 2-aryl-thiazolidine-4-carboxylic acid amides as potent and selective antiproliferative agents for melanoma. To understand the importance of the thiazolidine ring and to reduce potential complications associated with the two chiral centers, we designed and synthesized sets of new analogs by modifying this ring. These new analogs were tested in two melanoma cell lines and fibroblast cells (negative controls). Compared with the older analogs containing the thiazolidine ring, these new analogs have lower potency in general, but some of these analogs still have very good selectivity. These structure–activity studies indicated that the thiazolidine ring is very critical for the activity for these series of compounds.
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Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 11, 1 June 2008, Pages 3183–3187