کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376718 981964 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The discovery and optimization of pyrimidinone-containing MCH R1 antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The discovery and optimization of pyrimidinone-containing MCH R1 antagonists
چکیده انگلیسی

Optimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH R1) antagonists has provided compounds with potent and selective MCH R1 activity. Details of the optimization process are provided and the use of one of the compounds in an animal model of diet-induced obesity is presented.

Optimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH R1) antagonists has provided potent and selective compounds that are orally active in an animal model of obesity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 18, 15 September 2006, Pages 4723–4727
نویسندگان
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