کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376721 981964 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma
چکیده انگلیسی

Fatty acid synthase (FAS) is emerging as a potential therapeutic target to treat cancer and obesity. Bioassay-guided fractionation of a MeOH extract of the rhizomes of Dryopteris crassirhizoma (Dryopteridaceae), using an in vitro FAS inhibitory assay, resulted in the isolation of a series of acylphloroglucinols, as the active principles. The isolates 1–10 inhibited FAS with IC50 values ranging from 23.1 ± 1.4 to 71.7 ± 3.9 μM. The results of the present study indicate that the acylphloroglucinol derivatives could be considered to be a promising class of FAS inhibitors.

Bioassay-guided fractionation of a MeOH extract of the rhizomes of Dryopteris crassirhizoma led to the isolation of a series of acylphloroglucinols, as the active principles.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 18, 15 September 2006, Pages 4738–4742
نویسندگان
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