کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376723 981964 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide
چکیده انگلیسی

4,7-Difluoro-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione [4,7FPP-33 (14)] has a potent tubulin-polymerization-inhibiting activity comparable with those of the known tubulin-polymerization inhibitors rhizoxin and colchicine. The structure–activity relationship for fluorine substitution was elucidated.

4,7FPP-33 has been shown to possess potent tubulin polymerization inhibiting activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 18, 15 September 2006, Pages 4748–4751
نویسندگان
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