کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1376743 | 981964 | 2006 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and anti-tumor evaluation of new trisulfide derivatives Synthesis and anti-tumor evaluation of new trisulfide derivatives](/preview/png/1376743.png)
New bis-aromatic and heterocyclic trisulfide derivatives 5, 7–10 were synthesized by optimizing lead dibenzyl trisulfide natural product (4) to evaluate their anti-tumor activities. Five compounds 5–7, 9, and 10 exhibited potent anti-tumor activities against eight different tumor cell lines with low cytotoxicity against HepG2. Initial SAR was discussed, and MOA of these anti-microtubule agents was suggested based on cell kinetic response patterns observed on RT-CES system.
New bis-aromatic and heterocyclic trisulfide derivatives 5, 7–10 were synthesized by optimizing lead dibenzyl trisulfide natural product (4) to evaluate their anti-tumor activities. Five compounds 5–7, 9, and 10 exhibited potent anti-tumor activities against eight different tumor cell lines with low cytotoxicity against HepG2. Initial SAR was discussed, and MOA of these anti-microtubule agents was suggested based on cell kinetic response patterns observed on RT-CES system.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 18, 15 September 2006, Pages 4826–4829