کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376749 981964 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX
چکیده انگلیسی

New bis-pyridinium oxime reactivators connected with CH2O(CH2)nOCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N′-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent.

New bis-pyridinium oxime reactivators connected with CH2O(CH2)nOCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 18, 15 September 2006, Pages 4852–4855
نویسندگان
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