کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376779 | 981966 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The design and synthesis of novel α-ketoamide-based p38 MAP kinase inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The design and synthesis of novel α-ketoamide-based p38 MAP kinase inhibitors The design and synthesis of novel α-ketoamide-based p38 MAP kinase inhibitors](/preview/png/1376779.png)
چکیده انگلیسی
We have identified a novel series of potent p38 MAP kinase inhibitors through structure-based design which due to their extended molecular architecture bind, in addition to the ATP site, to an allosteric pocket. In vitro ADME and in vivo PK studies show these compounds to have drug-like characteristics which could result in the development of an oral treatment for inflammatory conditions.
The design and synthesis of novel α-ketoamide-based p38 inhibitors is reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 6, 15 March 2008, Pages 1772–1777
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 6, 15 March 2008, Pages 1772–1777
نویسندگان
Antonio Garrido Montalban, Erik Boman, Chau-Dung Chang, Susana Conde Ceide, Russell Dahl, David Dalesandro, Nancy G.J. Delaet, Eric Erb, Justin T. Ernst, Andrew Gibbs, Jeffrey Kahl, Linda Kessler, Jan Lundström, Stephen Miller, Hiroshi Nakanishi,