کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376825 981966 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as μ opioid receptor antagonists with improved opioid receptor selectivity profiles
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as μ opioid receptor antagonists with improved opioid receptor selectivity profiles
چکیده انگلیسی

A series of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines, μ opioid receptor antagonists, analogs of alvimopan, were prepared using solid phase methodology. This study led to the identification of a highly selective μ opioid receptor antagonist, which interacts selectively with μ peripheral receptors.

The discovery and SAR studies of a series of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as novel μ opioid receptor antagonists, analogs of alvimopan, are reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 6, 15 March 2008, Pages 2006–2012
نویسندگان
, , , , , , , , , , ,