کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376843 981966 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists
چکیده انگلیسی

The synthesis and SAR for a novel series of 2-alkyl-4-aryl-tetrahydro-pyrido-pyrimidines and 2-alkyl-4-aryl-tetrahydro-pyrimido-azepines is described. Representative compounds were shown to be subtype selective 5-HT2A antagonists. Optimal placement of a basic nitrogen relative to the pyrimidine and the presence of a 4-fluorophenyl group in the pyrimidine 4-position was found to have a profound effect on affinity and selectivity.

The synthesis and SAR for a novel series of 2-alkyl-4-aryl-tetrahydro-pyrido-pyrimidines and 2-alkyl-4-aryl-tetrahydro-pyrimido-azepines are described. Representative compounds were shown to be subtype selective 5-HT2A antagonists.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 6, 15 March 2008, Pages 2103–2108
نویسندگان
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