کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376854 981966 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adenosine analogues as inhibitors of P2Y12 receptor mediated platelet aggregation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Adenosine analogues as inhibitors of P2Y12 receptor mediated platelet aggregation
چکیده انگلیسی

Modified adenosine derivatives may lead to the development of P2Y12 antagonists that are potent, selective, and bind reversibly to the receptor. Analogues of 2′,3′-trans-styryl acetal-N6-ureido-adenosine monophosphate were prepared by modification of the 5′-position. The resulting analogues were tested for P2Y12 antagonism in a platelet aggregation assay.

Modified adenosine derivatives may lead to the development of P2Y12 antagonists that are potent, selective, and bind reversibly to the receptor. Analogues of 2′,3′-trans-styryl acetal-N6-ureido-adenosine monophosphate were prepared by modification of the 5′-position. The resulting analogues were tested for P2Y12 antagonism in a platelet aggregation assay. Compound 42 was found to be the most potent with an IC50 value of 40 nM.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 6, 15 March 2008, Pages 2167–2171
نویسندگان
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