کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376856 | 981966 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium](/preview/png/1376856.png)
چکیده انگلیسی
Three sesquiterpenoids, xanthatin (1), xanthinosin (2), and 4-oxo-bedfordia acid (3) were isolated from Xanthium strumarium as inhibitors of nitric oxide synthesis in activated microglia (IC50 values: 0.47, 11.2, 136.5 μM, respectively). Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-κB through the inhibition of LPS-induced I-κB-α degradation in microglia.
Three sesquiterpenoids from Xanthium strumarium (1, 2 and 3) inhibited the production of NO (IC50 = 0.47, 11.2, 136.5 μM, respectively), expression of iNOS/COX-2 and degradation of I-κB-α in activated microglia.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 6, 15 March 2008, Pages 2179–2182
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 6, 15 March 2008, Pages 2179–2182
نویسندگان
Jeong Hoon Yoon, Hyo Jin Lim, Hwa Jin Lee, Hee-Doo Kim, Raok Jeon, Jae-Ha Ryu,