کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376864 981966 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of novel series of human CCR1 antagonists
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Identification of novel series of human CCR1 antagonists
چکیده انگلیسی

A hit-to-lead optimization process was carried out on the high throughput screening hit compound 1 resulting in the identification of several potent and selective CCR1 receptor antagonists. Compound 37 shows the best overall profile with IC50 values of <100 nM in binding and functional assays.

A hit-to-lead optimization process on the high throughput screening hit compound 1 resulted in the identification of several potent and selective CCR1 receptor antagonists. Compound 37 shows the best overall profile with IC50 values of <0.01 μM in binding and functional assays.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 6, 15 March 2008, Pages 2215–2221
نویسندگان
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