کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376875 | 981967 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifs
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifs Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifs](/preview/png/1376875.png)
چکیده انگلیسی
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating biaryl P4 groups, producing highly potent inhibitors with encouraging oral pharmacokinetic profiles and significant but sub-optimal anticoagulant activities.
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating biaryl P4 groups, producing highly potent inhibitors with encouraging oral pharmacokinetic profiles and significant but sub-optimal anticoagulant activities.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 1, 1 January 2008, Pages 23–27
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 1, 1 January 2008, Pages 23–27
نویسندگان
Robert J. Young, Alan D. Borthwick, David Brown, Cynthia L. Burns-Kurtis, Matthew Campbell, Chuen Chan, Marie Charbaut, Chun-wa Chung, Máire A. Convery, Henry A. Kelly, N. Paul King, Savvas Kleanthous, Andrew M. Mason, Anthony J. Pateman,