Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives

A number of aminoalcohols, diamines and other related cycloanalogues of sphingosine have been synthesized and assayed in vitro against three Leishmania spp. and Trypanosoma cruzi. Most of the compounds were potent parasiticides, with IC50 values in the μM or lower range and potencies higher than those of pentamidine and benznidazol, the common therapeutic agents against these parasitoses.

Alkyl(alkylidene) substituted aminocyclohexanol derivatives and related compounds display in vitro anti-Leishmania and anti-Trypanosoma activities, with potencies higher than those of the clinically used reference drugs pentamidine, amphotericin B and benznidazol.Figure optionsDownload as PowerPoint slide