کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376907 981967 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds
چکیده انگلیسی

Six diarylbutane lignans 1–5 and one aryltetralin lignan 6 were isolated from the methanol (95%) extracts of Myristica fragrans seeds and then 7-methyl ether diarylbutane lignan 4 has proven to be new a compound. Their compounds 1–7 were evaluated for LDL-antioxidant activity to identify the most potent LDL-antioxidant 3 with an IC50 value of 2.6 μM in TBARS assay. Due to its potency, compound 3 was tested for complementary in vitro investigations, such as lag time (140 min at 1.0 μM), relative electrophoretic mobility (REM) of ox-LDL (inhibition of 80% at 20 μM and 72% at 10 μM), and fragmentation of apoB-100 (inhibition of 93% at 20 μM) on copper-mediated LDL oxidation. In macrophage-mediated LDL oxidation, the TBARS formation was also inhibited by compound 3.

Six diarylbutane lignans 1–5 and one aryltetralin lignan 6 were isolated from the ethyl acetate extracts of Myristica fragrans seeds and then 7-methyl ether diarylbutane lignan 4 has proven to be a new compound. Their compounds 1–7 were evaluated for LDL-antioxidant activity to identify the most potent LDL-antioxidant compound 3 with an IC50 value of 2.6 μM.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 1, 1 January 2008, Pages 194–198
نویسندگان
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