4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity

Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.

The synthesis and biological evaluation of 4-aminopyridine derivatives with anticholinesterase and antiamnesic activity is reported.Figure optionsDownload as PowerPoint slide