کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376942 | 981967 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure–activity relationships
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
The compound named Histidine–pyridine–histidine (HPH) is an oxygen-activating ligand derived from the structure of bleomycin. We synthesized HPH derivatives, namely HPH-1 to -8, and investigated their antiviral activities against herpes simplex virus type 1. HPH-8 showed potent antiviral activity with an EC50 of 15 μM, and relatively high cytotoxicity with a CC50 of 37 μM. In contrast, HPH-4 indicated a weaker antiviral activity with an EC50 of 79 μM, but exhibited a far more less cytotoxicity (CC50 500 μM). Other HPH derivatives showed no effects against antiviral activities and cytotoxicities.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 1, 1 January 2008, Pages 371–374
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 1, 1 January 2008, Pages 371–374
نویسندگان
Tetsuji Hosono, Kazumi Yokomizo, Akiyuki Hamasaki, Yoshinari Okamoto, Tadashi Okawara, Masami Otsuka, Ryozaburo Mukai, Keitarou Suzuki,