کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376942 981967 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure–activity relationships
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure–activity relationships
چکیده انگلیسی

The compound named Histidine–pyridine–histidine (HPH) is an oxygen-activating ligand derived from the structure of bleomycin. We synthesized HPH derivatives, namely HPH-1 to -8, and investigated their antiviral activities against herpes simplex virus type 1. HPH-8 showed potent antiviral activity with an EC50 of 15 μM, and relatively high cytotoxicity with a CC50 of 37 μM. In contrast, HPH-4 indicated a weaker antiviral activity with an EC50 of 79 μM, but exhibited a far more less cytotoxicity (CC50 500 μM). Other HPH derivatives showed no effects against antiviral activities and cytotoxicities.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 1, 1 January 2008, Pages 371–374
نویسندگان
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