کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376952 | 981967 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor](/preview/png/1376952.png)
چکیده انگلیسی
Based on a lead compound identified from the patent literature, we developed patentably novel BACE-1 inhibitors by introducing a cyclic amine scaffold as embodied by 1a and 1b. Extensive SAR studies assessed a variety of isophthalamide replacements including substituted pyrrolidinones and ultimately led to the identification of 11. Due to its favorable overall profile, 11 has been extensively profiled in various in vivo settings.
Extensive SAR studies led to the identification of 11, which has been extensively profiled in various in vivo settings.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 1, 1 January 2008, Pages 418–422
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 1, 1 January 2008, Pages 418–422
نویسندگان
U. Iserloh, J. Pan, A.W. Stamford, M.E. Kennedy, Q. Zhang, L. Zhang, E.M. Parker, N.A. McHugh, L. Favreau, C. Strickland, J. Voigt,