کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376971 | 981968 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of butynyloxyphenyl β-sulfone piperidine hydroxamates as TACE inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design and synthesis of butynyloxyphenyl β-sulfone piperidine hydroxamates as TACE inhibitors Design and synthesis of butynyloxyphenyl β-sulfone piperidine hydroxamates as TACE inhibitors](/preview/png/1376971.png)
چکیده انگلیسی
A series of butynyloxyphenyl β-sulfone piperidine hydroxamate TACE inhibitors was designed and synthesized. The resulting structure–activity relationship and MMP selectivity of the series were examined. Of the compounds investigated, 17s has excellent in vitro potency against isolated TACE enzyme, shows good selectivity over MMP-1, -2, -7, -8, -9, -13, and -14, and oral activity in an in vivo mouse model of TNF-α production.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 15, 1 August 2006, Pages 3927–3931
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 15, 1 August 2006, Pages 3927–3931
نویسندگان
Kaapjoo Park, Alexis Aplasca, Mila T. Du, LinHong Sun, Yi Zhu, Yuhua Zhang, Jeremy I. Levin,