کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377011 | 981968 | 2006 | 4 صفحه PDF | دانلود رایگان |
An early diagnosis of cancer is crucial in the battle against this disease and the in vivo visualization of tumors at cellular level is still the most challenging goal. In order to target tumor cells, we took into account their increased metabolism and amino acid nutrients or pseudo-nutrients, which are actively transported through the cell membrane, have been chosen as vectors for new MRI contrast agents. For this reason new gadolinium complexes conjugated to agmatine, arginine, and glutamine have been synthesized and studied.
With the aim of discovering an early diagnosis of cancer by magnetic resonance imaging (MRI), we synthesized and studied six DTPA and DOTA-like gadolinium complexes conjugated to agmatine, arginine, and glutamine (e.g., 7a), able to target tumor cells by means of the glutamine transport system.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 15, 1 August 2006, Pages 4111–4114