کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377130 981971 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity
چکیده انگلیسی

Here we present an efficient route into synthetically challenging bridged 1,2,4,5-tetraoxanes. The key to the success of this route is the use of H2O2 and catalytic I2 to form the gem-dihydroperoxide followed by a Ag2O mediated alkylation using 1,3-diiodopropane. Using this methodology a range of bridged tetraoxanes which display good in vitro antimalarial activity were synthesized.

Here we present an efficient route into the synthetically challenging bridged 1,2,4,5-tetraoxanes. These achiral derivatives display nanomolar antimalarial activity (IC50 = 40–100 nM).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 5, 1 March 2008, Pages 1720–1724
نویسندگان
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