کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1377141 | 981972 | 2007 | 4 صفحه PDF | دانلود رایگان |
We have proven that xanthones 1–8 isolated from the root of C. tricuspidata possess highly potent αα-glucosidase inhibition properties. Compound 1 was identified as a new isoprenylated tetrahydroxy xanthone, 1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)-8-(2-methylbut-3-en-2-yl)-9H-xanthen-9-one (1). These are the first natural xanthones documented to exhibit such inhibition. The IC50 values of compounds 1–8 inhibiting α-glucosidase activity were determined to be up to 16.2 μM. Mechanistic analysis showed the xanthones 1–8 exhibited full mixed inhibition.
Eight α-glucosidase inhibitory xanthones were isolated from Cudrania Tricuspidata. Compound 1 was identified as the new isoprenylated tetrahydroxy xanthone. The IC50 value of the most effective xanthone 7 was 16.2 μM.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 23, 1 December 2007, Pages 6421–6424