Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification

High throughput screening combined with efficient datamining and parallel synthesis led to the discovery of a novel series of indolines showing potent in vitro ghrelin receptor agonist activity and acceleration of gastric emptying in rats.

A series of indolines showing potent in vitro ghrelin receptor agonism and acceleration of gastric emptying in rats is described.Figure optionsDownload as PowerPoint slide