کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377185 | 981972 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of novel isoxazolines as anti-tuberculosis agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discovery of novel isoxazolines as anti-tuberculosis agents Discovery of novel isoxazolines as anti-tuberculosis agents](/preview/png/1377185.png)
چکیده انگلیسی
Nitrofuranyl isoxazolines with increased proteolytic stability over nitrofuranyl amides were designed and synthesized leading to discovery of several compounds with potent in vitro anti-tuberculosis activity. However, their in vivo activity was limited by high protein binding and poor distribution. Consequently, a series of non-nitrofuran containing isoxazolines were prepared to determine if the core had residual anti-tuberculosis activity. This led to the discovery of novel isoxazoline 12 as anti-tuberculosis agent with a MIC90 value of 1.56 μg/mL.
Discovery of isoxazoline compound 12 as novel anti-tuberculosis agent (MIC90 = 1.56 μg/mL) is reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 23, 1 December 2007, Pages 6638–6642
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 23, 1 December 2007, Pages 6638–6642
نویسندگان
Rajendra P. Tangallapally, Dianqing Sun, Rakesh, Nageshwar Budha, Robin E.B. Lee, Anne J.M. Lenaerts, Bernd Meibohm, Richard E. Lee,