کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1377188 | 981972 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli](/preview/png/1377188.png)
A new small molecule inhibitor of bacterial cell division has been discovered using a high-throughput screen in Escherichia coli. Although the lead screening hit (534F6) exhibited modest inhibition of the GTPase activity of FtsZ (20 ± 5% at 100 μM of compound), a primary target for bacterial cell division inhibitors, several analogs caused potent bacterial growth inhibition with negligible antagonism of FtsZ GTPase activity. A library of analogs has been prepared and several alkyne-tagged photoaffinity probes have been synthesized for use in experiments to elucidate the primary target of this compound.
The discovery and preliminary development of a new class of compounds that target bacterial cell division is reported.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 23, 1 December 2007, Pages 6651–6655