کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377227 981974 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of 4-substitution on psychotomimetic activity of 2,5-dimethoxy amphetamines as studied by means of different substituent parameter scales
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Effect of 4-substitution on psychotomimetic activity of 2,5-dimethoxy amphetamines as studied by means of different substituent parameter scales
چکیده انگلیسی

Electron-withdrawing substituents at position 4 of 2,5-dimethoxy-substituted amphetamines increase, whereas electron-donating substituents decrease the psychotomimetic activity. The origin of this clearly localized effect is discussed. The uses of modified Hammett substituent scales (σ− and σ+), and especially the good σ+ correlation, strongly suggest that electron-donating substituents decrease the biological activity through a specific effect relating to the extent of the conjugative electron release from the 5-methoxy group to the phenyl ring.

Electron-donating substituents decrease the psychotomimetic activity trough a specific effect relating to the diminution of the conjugative electron release from the 5-methoxy group to the phenyl ring.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 13, 1 July 2006, Pages 3495–3498
نویسندگان
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