Synthesis of Hsp90 dimerization modulators

The synthesis and evaluation of several chemical modulators of heat shock protein 90 (Hsp90) dimerization is presented. These agents may represent useful tools to study the importance of N-terminal dimerization and also to determine subunit interface(s) in Hsp90.

The synthesis and evaluation of several Hsp90 chemical modulators is reported.Figure optionsDownload as PowerPoint slide