کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377314 | 981976 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents](/preview/png/1377314.png)
A series of 3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (2a–h) and 1-benzoyl-3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (3a–h) were synthesized by condensation of chalcones with hydrazine hydrate in solvent system ethanol and DMF. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activity, and were compared with standard drug. Among the compounds studied, compound 2e showed more potent anti-inflammatory and analgesic activity than the standard drug, along with minimum ulcerogenic index.
A series of 3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (2a–h) and 1-benzoyl-3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (3a–h) were synthesized by condensation of chalcones with hydrazine hydrate in solvent system ethanol and DMF. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activity, and were compared with standard drug flurbiprofen.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 3, 1 February 2008, Pages 918–922