کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377366 981976 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Three-component, one-pot synthesis of novel 2,4-substituted 5-azolylthiopyrimidine library for screening against anti-influenza virus A
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Three-component, one-pot synthesis of novel 2,4-substituted 5-azolylthiopyrimidine library for screening against anti-influenza virus A
چکیده انگلیسی

A novel one-pot synthesis of 2,4-substituted 5-azolylthiopyrimidines is achieved by sequential Michael-addition of 3-iodochromones with mercaptoazole (or mercaptotriazoles) and then condensation with a variety of amidines. Compound A1B6C1 exhibits a potent anti-influenza virus A activity with an IC50 value of 21.56 mg/mL and SI value of 9.

A novel three-component, one-pot reaction synthesize, 2,4-substituted 5-azolylthiopyrimidines and Compound A1B6C1 exhibits a potent anti-influenza virus A activity (IC50 = 21.56 mg/mL).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 3, 1 February 2008, Pages 1177–1180
نویسندگان
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