کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377386 | 981977 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo.
The synthesis of a series of new bisphenol derivatives bearing allylic moieties as potential analogs of honokiol and/or magnolol is reported. Certain compounds exhibited specific anti-proliferation activity and moderate anti-HIV-1 activity in vitro.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 16, 15 August 2007, Pages 4428–4431
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 16, 15 August 2007, Pages 4428–4431
نویسندگان
Franck Amblard, Baskaran Govindarajan, Benjamin Lefkove, Kimberly L. Rapp, Mervi Detorio, Jack L. Arbiser, Raymond F. Schinazi,