کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377448 | 981979 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and SAR of α-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and SAR of α-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors Synthesis and SAR of α-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors](/preview/png/1377448.png)
چکیده انگلیسی
A series of novel carboxylic acid-based α-sulfone MMP inhibitors have been synthesized and the in vitro enzyme SAR is discussed. A potential binding mode in the active site of the MMP-9 homology model was highlighted. These compounds are potent MMP-9 inhibitors and are selective over MMP-1.
A series of novel carboxylic acid-based α-sulfone MMP inhibitors have been synthesized and the in vitro enzyme SAR and in vivo PK evaluation are discussed. These compounds are potent MMP-9 inhibitors and are selective over MMP-1.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 12, 15 June 2006, Pages 3096–3100
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 12, 15 June 2006, Pages 3096–3100
نویسندگان
Yue-Mei Zhang, Xiaodong Fan, Bangping Xiang, Devraj Chakravarty, Robert Scannevin, Sharon Burke, Prabha Karnachi, Kenneth Rhodes, Paul Jackson,