کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377476 | 981979 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A pyrimidine–pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A pyrimidine–pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity A pyrimidine–pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity](/preview/png/1377476.png)
چکیده انگلیسی
Synthetic hybridization of two privileged drug scaffolds, pyrazolone on the one hand and pyrimidine nucleoside on the other, resulted in the generation of two novel 5-substituted pyrimidine nucleosides with potent in vitro antiviral activity against two representative orthopoxviruses, vaccinia virus and cowpox virus.
5-Formyl-2′-deoxyuridine was condensed with 1-phenyl-3-methyl-2-pyrazolin-5-one to give a novel pyrimidinylidene–pyrazolone nucleoside (9) with potent in vitro anti-orthopoxvirus properties.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 12, 15 June 2006, Pages 3224–3228
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 12, 15 June 2006, Pages 3224–3228
نویسندگان
Xuesen Fan, Xinying Zhang, Longhu Zhou, Kathy A. Keith, Earl R. Kern, Paul F. Torrence,