کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1377485 | 981979 | 2006 | 6 صفحه PDF | دانلود رایگان |
Adenophorine and its 5-deoxy analogue have been identified as natural iminosugars with efficient glycosidase inhibitory effects. The syntheses and biological evaluation of two new series of 5-deoxyadenophorine analogues in their racemic form are reported. The compounds 12e and 13d bearing a C11 and C7 alkyl chain, respectively, were found to be potent inhibitors of the β-glucosidase from almond with Ki near to 60 μM. The compounds 13a,d which possess a 3,4-cis stereochemistry were efficient on glucosidases but also on the β-galactosidase, what was not observed with the 3,4-trans series 12.
Two series of novel analogues of 5-deoxyadenophorine with lipophilic side-chains (C2–C11) are prepared and tested on a range of glycosidases.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 12, 15 June 2006, Pages 3262–3267