کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377515 | 981981 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials](/preview/png/1377515.png)
چکیده انگلیسی
Oxazolidinone analogs bearing substituted piperidine or azetidine C-rings are described. Analogs with a methyl group at the 3-position of the azetidine ring or the 4-position of the piperidine ring exhibited reduced mitochondrial protein synthesis inhibition while retaining good antibacterial potency.
Oxazolidinone analogs bearing substituted piperidine or azetidine C-rings are described. Analogs with a methyl group at the 3-position of the azetidine ring or the 4-position of the piperidine ring exhibited reduced mitochondrial protein synthesis inhibition while retaining good antibacterial potency.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 18, 15 September 2007, Pages 5036–5040
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 18, 15 September 2007, Pages 5036–5040
نویسندگان
Adam R. Renslo, Andy Atuegbu, Prudencio Herradura, Priyadarshini Jaishankar, Mingzhe Ji, Karen L. Leach, Michael D. Huband, Michael R. Dermyer, Luping Wu, J.V.N. Vara Prasad, Mikhail F. Gordeev,