کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377519 | 981981 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A host-rotaxane derivatized with carboxylic acids efficiently delivers a highly cationic fluoresceinated peptide
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A host-rotaxane derivatized with carboxylic acids efficiently delivers a highly cationic fluoresceinated peptide A host-rotaxane derivatized with carboxylic acids efficiently delivers a highly cationic fluoresceinated peptide](/preview/png/1377519.png)
چکیده انگلیسی
A cleft-[2]rotaxane (CR2+2−) was derivatized with carboxylic acids to enhance the intracellular delivery of a highly cationic or anionic pentapeptide. CR2+2− delivers the fluorescein (Fl) tagged peptide Fl-KKALR to a greater amount than Fl-QEAVD, and at a higher concentration, a greater amount than Fl-AVWAL. The level of delivery is largely temperature and ATP independent, suggesting that the Fl-peptide·CR2+2− complexes pass through the cellular membrane without requiring active cell-mediated processes. This study shows that selective delivery of peptides is possible by using a suitably derivatized host-rotaxane as the transporter.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 18, 15 September 2007, Pages 5058–5062
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 18, 15 September 2007, Pages 5058–5062
نویسندگان
Jing Zhu, Brian E. House, Erin Fleck, Idit Isaacsohn, Angela F. Drew, David B. Smithrud,