کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377551 | 981981 | 2007 | 4 صفحه PDF | دانلود رایگان |
A series of 3-substituted-1(3H)-isobenzofuranone 6a–g and 7a–g were synthesized from phthalic anhydride. The compound 6a–g was resolved. The antiplatelet activities of these compounds were evaluated using in vitro experiment of platelet aggregation. The levels of antiplatelet activity were displayed as following sequence: l-isomer > dl-isomer > d-isomer, respectively. The alkylphthalide is more active than the corresponding alkenephthalide. All these compounds were less active than n-butylphthalide (NBP, 6c) and Aspirin (Asp).
A series of 3-substituted-1(3H)-isobenzofuranone 6a–g and 7a–g were synthesized from phthalic anhydride. 3-alkyl-1(3H)-isobenzofuranone were resoluted. The antiplatelet activities of compounds were evaluated.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 18, 15 September 2007, Pages 5210–5213