Synthesis and structure–activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor γ (PPARγ) agonists

A series of novel indene N-oxide derivatives were prepared by various synthetic methods and evaluated for their ability to activate PPARγ. The best PPARγ agonist in this series was 9 h, which showed an EC50 value of 15 nM.

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