کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377560 | 981981 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and optimization of novel and selective muscarinic M3 receptor antagonists
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of constrained piperidine analogues were synthesized as novel muscarinic M3 receptor antagonists. Evaluation of these compounds in binding assays revealed that they not only have high affinity for the M3 receptor but also have high selectivity over the M2 receptor.
A series of constrained piperidine derivatives were synthesized as muscarinic M3 receptor antagonists. In vitro evaluation of these compounds reveals high affinity for the M3 receptor and high selectivity over the M2 receptor.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 18, 15 September 2007, Pages 5256–5260
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 18, 15 September 2007, Pages 5256–5260
نویسندگان
Naresh Kumar, Kirandeep Kaur, Shelly Aeron, Sankaranarayanan Dharmarajan, Arun D.V. Silamkoti, Anita Mehta, Suman Gupta, Anita Chugh, Jang B. Gupta, Mohammad Salman, Venkata P. Palle, Ian A. Cliffe,