کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377615 | 981982 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
An iodine-123 labeled bicyclic nucleoside analogue ([123I]-4) has been synthesized and evaluated as a potential single photon emission tomography (SPECT) reporter probe for the non-invasive imaging of expression of the varicella zoster virus thymidine kinase (VZV-tk) reporter gene. In vitro enzymatic assays revealed that the non-radioactive mono-iodo derivative 4 has good affinity for VZV-TK (IC50: 4.2 μM). Biodistribution of [123I]-4 was examined in normal mice. Evaluation of [123I]-4 in HEK-293T cells showed 1.74-fold higher accumulation in VZV-TK-expressing cells compared to control cells.
An 123I-labeled BCNA that has good affinity for VZV-TK (IC50: 4.2 μM) is synthesized and evaluated.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 12, 15 June 2007, Pages 3458–3462
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 12, 15 June 2007, Pages 3458–3462
نویسندگان
Satish K. Chitneni, Christophe M. Deroose, Humphrey Fonge, Rik Gijsbers, Natalia Dyubankova, Jan Balzarini, Zeger Debyser, Luc Mortelmans, Alfons M. Verbruggen, Guy M. Bormans,