کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377692 | 981986 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A new series of 1,2,4-triazoles was synthesized and tested against several NNRTI-resistant HIV-1 isolates. Several of these compounds exhibited potent antiviral activities against efavirenz- and nevirapine-resistant viruses, containing K103N and/or Y181C mutations or Y188L mutation. Triazoles were first synthesized from commercially available substituted phenylthiosemicarbazides, then from isothiocyanates, and later by condensing the desired substituted anilines with thiosemicarbazones.
A new series of 1,2,4-triazoles was synthesized and tested against several NNRTI-resistant HIV-1 isolates containing K103N and/or Y181C mutations or Y188L mutation.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 17, 1 September 2006, Pages 4444–4449
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 17, 1 September 2006, Pages 4444–4449
نویسندگان
Martha De La Rosa, Hong Woo Kim, Esmir Gunic, Cheryl Jenket, Uyen Boyle, Yung-hyo Koh, Ilia Korboukh, Matthew Allan, Weijian Zhang, Huanming Chen, Wen Xu, Shahul Nilar, Nanhua Yao, Robert Hamatake, Stanley A. Lang, Zhi Hong, Zhijun Zhang,