Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands

A series of 2–9a bridged tetrahydrofluorenone derivatives were prepared which exhibited significant binding affinity for ERβ and were highly selective.

A series of 2-9a bridged tetrahydrofluorenone derivatives were prepared which exhibited significant binding affinity for ERβ and high selectivity for ERβ over ERα.Figure optionsDownload as PowerPoint slide