کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377697 981986 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metabolism investigation leading to novel drug design 2: Orally active prostacyclin mimetics. Part 5
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Metabolism investigation leading to novel drug design 2: Orally active prostacyclin mimetics. Part 5
چکیده انگلیسی

A metabolism study of FK788 (2) led to the discovery of new diphenylcarbamoyl derivatives as prostacyclin mimetics without the PG skeleton. We designed and evaluated PGI2 mimetics based on blocking the main metabolic pathway of FK788. The new compound 7c was found to be equipotent to FK788 towards PGI2 agonist activity and metabolically more stable than FK788.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 17, 1 September 2006, Pages 4475–4478
نویسندگان
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