Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements

A series of pyrrolopyridine-substituted oxazolidinones containing various C-5 acetamide isosteres was synthesized and the structure–antibacterial activity relationships determined against a representative panel of susceptible and resistant Gram-positive bacteria.

A series of pyrrolopyridine-substituted oxazolidinones containing various C-5 acetamide isosteres was synthesized and the structure–antibacterial activity relationships determined against a representative panel of susceptible and resistant Gram-positive bacteria.Figure optionsDownload as PowerPoint slide