کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377762 981987 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
N-Hydroxythiosemicarbazones: Synthesis and in vitro antitubercular activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
N-Hydroxythiosemicarbazones: Synthesis and in vitro antitubercular activity
چکیده انگلیسی

N-Hydroxythiosemicarbazide was prepared by two methods starting from 2,4-dimethoxy benzyl amine and hydroxylamine hydrochloride, which in turn was reacted with various aldehydes and ketones to obtain the titled compounds. Eighteen compounds were tested for their in vitro activity against Mycobacterium tuberculosis H37Rv using the agar dilution method. Compound 10p was found to be the most potent compound (MIC: 0.28 μM) and was 2.5 times more active than standard isoniazid.

Eighteen N-hydroxythiosemicarbazones were prepared and tested for their in vitro activity against Mycobacterium tuberculosis H37Rv using the agar dilution method.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 7, 1 April 2007, Pages 1888–1891
نویسندگان
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