کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377775 981987 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of unprecedented classes of spiro-β-lactams and azido-β-lactams as acyl-CoA:cholesterol acyltransferase inhibitors
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of unprecedented classes of spiro-β-lactams and azido-β-lactams as acyl-CoA:cholesterol acyltransferase inhibitors
چکیده انگلیسی

Unprecedented classes of four- and five-membered hydroxyl-spiro-β-lactams and hydroxyl-azido-β-lactams were prepared via regioselective ring opening of hydroxyl-epoxides. The potential of these particular β-lactams as biologically active compounds has been confirmed by the results obtained in ACAT inhibition assays.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 7, 1 April 2007, Pages 1946–1950
نویسندگان
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