کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377792 | 981987 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases](/preview/png/1377792.png)
چکیده انگلیسی
Novel C-5 substituted pyrrolotriazines were optimized for dual EGFR and HER2 protein tyrosine kinase inhibition. The lead compound exhibited promising oral efficacy in both EGFR and HER2 driven human tumor xenograft models. It is hypothesized that its C-5 morpholine side chain binds in the ribose phosphate portion of the ATP binding pocket.
Novel C-5 substituted pyrrolotriazines were optimized for dual EGFR and HER2 protein tyrosine kinase inhibition. The lead compound exhibited promising oral efficacy in both EGFR and HER2 driven human tumor xenograft models. It is hypothesized that its C-5 morpholine side chain binds in the ribose phosphate portion of the ATP binding pocket.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 7, 1 April 2007, Pages 2036–2042
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 7, 1 April 2007, Pages 2036–2042
نویسندگان
Harold Mastalerz, Ming Chang, Ping Chen, Pierre Dextraze, Brian E. Fink, Ashvinikumar Gavai, Bindu Goyal, Wen-Ching Han, Walter Johnson, David Langley, Francis Y. Lee, Punit Marathe, Arvind Mathur, Simone Oppenheimer, Edward Ruediger, James Tarrant,